Which type of packaging must be unopened and intact for drug returns to stock?

Unit-dose packaging is designed for single use and contains medications that are individually packaged to maintain their integrity and safety until administered to a patient. This type of packaging is critical in ensuring that the medication remains uncontaminated and safe to use. Because of this individual packaging, a unit-dose must be unopened and intact for it to be accepted back into stock. Any damage or tampering could compromise the sterility or efficacy of the medication, making it unsuitable for re-dispensing or administration.

In contrast, loose packaging, bulk packaging, and partial containers do not provide the same level of security or assurance about the integrity of the medication. Loose packages may have an increased risk of contamination, while bulk packaging isn't intended for individual patient dosing and may not be suitable for direct return to stock. Partial containers pose similar risks, as they represent leftover medication that once opened, cannot guarantee the medication’s potency or integrity. Thus, the requirement for unopened and intact drug returns is specific to unit-dose packaging to uphold safety and quality standards in pharmacy practice.