Which of the following statements is true regarding Schedule I controlled substances?

Schedule I controlled substances are classified as having a high potential for abuse, and they are not currently accepted for medical use in treatment within the United States. This classification is significant because it reflects the strict regulatory environment surrounding these substances, indicating that they pose a greater risk for addiction and misuse compared to those in other schedules.

Substances in Schedule I, such as heroin or LSD, are considered to have no accepted medical applications in the U.S., which distinguishes them from substances in lower schedules that may have medical uses, albeit with restrictions. This implies that they cannot be prescribed by healthcare practitioners or dispensed by pharmacies, underscoring the severity of their classification.

The other statements do not accurately represent the characteristics of Schedule I controlled substances. For instance, options suggesting they can be prescribed or have accepted medical uses contradict the foundational criteria used to classify substances in this schedule. Additionally, the notion of over-the-counter availability is wholly incompatible with the regulatory framework for Schedule I drugs, as they are only accessible through illegal means.